10 Recent original Publications:

  1. Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M and Becher B. High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease. Immunity. 2018;48(2):380-95 e6
  1. Krieg C, Nowicka M, Guglietta S, Schindler S, Hartmann FJ, Weber LM, Dummer R, Robinson MD, Levesque MP, and Becher B. High dimensional single cell analysis predicts response to anti-PD-1 immunotherapy, Nat. Med. 2018;24(2):144-153
  1. Spath S, Komuczki J, Hermann M, Pelczar P, Mair F, Schreiner B and Becher B. Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System. Immunity. 2017;46(2):245-60.
  1. Croxford AL, Lanzinger M, Hartmann FJ, Schreiner B, Mair F, Pelczar P, Clausen BE, Jung S, Greter M and Becher B. The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2(+) Monocytes and Licenses Autoimmunity. Immunity. 2015;43(3):502-14.
  1. Becher B, Schlitzer A, Chen J, Mair F, Sumatoh HR, Teng KW, Low D, Ruedl C, Riccardi-Castagnoli P, Poidinger M, Greter M, Ginhoux F and Newell EW. High-dimensional analysis of the murine myeloid cell system. Nat Immunol. 2014.
  1. Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, Kundig TM, Frei K, Ginhoux F, Merad M and Becher B (2012) Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia. Immunity 37: 1050-1060.
  1. Vom Berg J, Prokop S, Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Heppner FL* and Becher B* (2012) Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat Med 18: 1812-1819.
  1. Locatelli G, Wortge S, Buch T, Ingold B, Frommer F, Sobottka B, Kruger M, Karram K, Buhlmann C, Bechmann I, Heppner FL, Waisman A and Becher B (2012) Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat Neurosci 15: 543-550.
  1. Codarri L, Gyülveszi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T and Becher B (2011) RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12: 560-567.
  1. Eisenring M, vom Berg J, Kristiansen G, Saller E and Becher B (2010) IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11: 1030-1038.

Selected Reviews:

  1. Becher B, Waisman A and Lu LF. Conditional Gene-Targeting in Mice: Problems and Solutions. Immunity. 2018;48(5):835-6.
  1. Becher B, Spath S and Goverman J. Cytokine networks in neuroinflammation. Nat Rev Immunol. 2017;17(1):49-59.
  1. Becher B, Tugues S and Greter M. GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation. Immunity. 2016;45(5):963-73.
  1. Mair F, Hartmann FJ, Mrdjen D, Tosevski V, Krieg C and Becher B. The end of gating? An introduction to automated analysis of high dimensional cytometry data. Eur J Immunol. 2016;46(1):34-43.
  1. Croxford AL, Spath S and Becher B. GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage. Trends Immunol. 2015;36(10):651-62.
  1. Heppner FL, Ransohoff RM and Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015;16(6):358-72.
  1. Tugues S, Burkhard SH, Ohs I, Vhrolings M, Nussbaum K, vom Berg j, Kulig P and Becher B. New insights into IL-12 mediated tumor suppression. Cell Death Differ. 2015;22(2):237-46.
  1. Becher B and Pantelyushin S (2012) Hiding under the skin: Interleukin-17-producing gammadelta T cells go under the skin? Nat Med 18: 1748-1750.