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Institute of Experimental Immunology Inflammation Research

Selected original Publications (past 5 years):

  1. Ingelfinger, Florian et al. “Twin study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis.” Med (New York, N.Y.) vol. 5,4 (2024): 368-373.e3. doi:10.1016/j.medj.2024.02.013
  2. Wertheimer, Tobias et al. “IL-23 stabilizes an effector Treg cell program in the tumor microenvironment.” Nature immunology vol. 25,3 (2024): 512-524. doi:10.1038/s41590-024-01755-7
  3. Andreadou, Myrto et al. “IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice.” Nature Neuroscience , vol. 26,10 (2023): 1701-1712, doi:10.1038/s41593-023-01435-z
  4. Nuñez, Nicolás Gonzalo et al. “High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity.” Nature Immunology , vol. 24,6 (2023): 941-954, doi:10.1038/s41590-023-01499-w
  5. Paust HJ, Song N, De Feo D, et al. CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12. Sci Transl Med. 2023 Mar 15;15(687):eadd6137, doi:10.1126/scitranslmed.add6137
  6. Nuñez NG, Berner F, Friebel E, et al. Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors. Med. 2023 Feb 10;4(2):113-129.e7, doi:10.1016/j.medj.2022.12.007
  7. Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht, A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B. Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature. 2022 Mar;603(7899):152-158, doi:10.1038/s41586-022-04419-4
  8. Amorim A, De Feo D, Friebel E, Ingelfinger F, Anderfuhren CD, Krishnarajah S, Andreadou M, Welsh CA, Liu Z, Ginhoux F, Greter M, Becher B. IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation. Nat Immunol. 2022 Feb;23(2):217-228, doi:10.1038/s41590-021-01117-7
  9. Krishnarajah S, Ingelfinger F, Friebel E, Cansever D, Amorim A, Andreadou M, Bamert D, Litscher G, Lutz M, Mayoux M, Mundt S, Ridder F, Sparano C, Stifter SA, Ulutekin C, Unger S, Vermeer M, Zwicky P, Greter M, Tugues S, De Feo D, Becher B. Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice. Nat Aging. 2022 Jan;2(1):74-89, doi:10.1038/s43587-021-00148-x
  10. Haftmann C, Zwicky P, Ingelfinger F, Mair F, Floess S, Riedel R, Durek P, Spalinger MR, Friebel E, Leung BP, Lutz M, Puertas N, Amorim A, Schärli S, Becher B, Kisielow J, Waisman A, Mashreghi MF, Huehn J, Becher B. Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg cell development. Sci Immunol. 2021 Nov 19;6(65):eabf3111, doi:10.1126/sciimmunol.abf3111
  11. Zwicky P, Ingelfinger F, Silva de Melo BM, Ruchti F, Schärli S, Puertas N, Lutz M, Phan TS, Kündig TM, Levesque MP, Maul JT, Schlapbach C, LeibundGut- Landmann S, Mundt S, Becher B. IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Sci Immunol. 2021 Oct 22;6(64):eabg9012, doi:10.1126/sciimmunol.abg9012
  12. Kreutmair S, Unger S, Núñez NG, Ingelfinger F, Alberti C, De Feo D, Krishnarajah S, Kauffmann M, Friebel E, Babaei S, Gaborit B, Lutz M, Jurado NP, Malek NP, Goepel S, Rosenberger P, Häberle HA, Ayoub I, Al-Hajj S, Nilsson J, Claassen M, Liblau R, Martin-Blondel G, Bitzer M, Roquilly A, Becher B. Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia. Immunity. 2021 Jul 13;54(7):1578-1593.e5, doi:10.1016/j.immuni.2021.05.002
  13. Friebel E, Kapolou K, Unger S, Núñez NG, Utz S, Rushing EJ, Regli L, Weller M, Greter M, Tugues S, Neidert MC, Becher B. Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes. Cell. 2020 Jun 25;181(7):1626-1642.e20, doi:10.1016/j.cell.2020.04.055

Selected Reviews:

  1. Van Hove H, De Feo D, Greter M, Becher B. Central Nervous System Macrophages in Health and Disease. Annu Rev Immunol. 2025 Apr;43(1):589-613. doi:10.1146/annurev-immunol-082423-041334
  2. Gogoleva, Violetta S et al. “Mononuclear phagocytes in autoimmune neuroinflammation.” Trends in immunology vol. 45,10 (2024): 814-823. doi:10.1016/j.it.2024.08.005
  3. Becher, Burkhard et al. “Targeting cytokine networks in neuroinflammatory diseases.” Nature reviews. Drug discovery vol. 23,11 (2024): 862-879. doi:10.1038/s41573-024-01026-y
  4. Mundt S, Greter M, Becher B. The CNS mononuclear phagocyte system in health and disease. Neuron. 2022;110(21):3497-3512. doi:10.1016/j.neuron.2022.10.005
  5. Ingelfinger F, Beltrán E, Gerdes LA, Becher B. Single-cell multiomics in neuroinflammation. Curr Opin Immunol. 2022 Jun;76:102180. doi:10.1016/j.coi.2022.102180
  6. Tuzlak, Selma et al. Repositioning TH cell polarization from single cytokines to complex help. Nature immunology vol. 22,10 (2021): 1210-1217. doi:10.1038/s41590-021-01009-w

Additional Information

PubMed

Publications

You will find an up-to-date list of our publications on the PubMed website.