Selected Publications

1. Tugues S*,#, Amorim A*, Spath S*, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Nunez N, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B# (2018). * Equal contribution # Corresponding author. Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells.

Science Translational Medicine. Nov; 10 (469).

 

2. Beffinger M, Tallon de Lara P, Tugues S, Vermeer M, Montagnolo Y, Ohs I, Cecconi V, Lucchiari G, Gagliardi A, Misljencevic N, Sutton J, Spörri R, Becher B, Gupta A, van den Broek M (2018). CSF1R-dependent myeloid cells are required for NK cell-mediated control of metastasis.

JCI Insight. May;17: 3-10.

 

3. Mathew NR, Baumgartner F, Braun L, O’Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert L, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz A, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D,  Mackensen A, von Bubnoff N, Herr W, Becher B, Socie G, Caligiuri M, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R (2018). Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD mutant leukemia cells.

Nature Medicine. Apr; 25:526.

 

4. Ohs I, Ducimetiere L, Marinho J, Kulig P, Becher B*#, Tugues S*#, (2017). * Equal contribution # Corresponding author. Restoration of natural killer cell anti-metastatic activity by IL-12 and checkpoint blockade.

Cancer Research. Dec; 77: 7059-7071.

 

5. Nussbaum K, Burkhard SH, Ohs I, Mair F, Klose CSN, Arnold SJ, Diefenbach A, Tugues S, Becher B (2017). Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs.

The Journal of Experimental Medicine. Aug; 214: 2331-2347.

 

6. Ohs I, van den Broek M, Nussbaum K, Münz C, Arnold SJ, Quezada SA, Tugues S*, Becher B* (2016). * Equal contribution. Interleukin-12 bypasses common gamma-chain signaling in emergency natural killer cell lymphopoiesis.

Nature Communications. Dec; 7:13708.

 

7. Becher B, Tugues S, Greter M (2016). GM-CSF: from growth factor to central mediator of tissue inflammation.

Immunity. Nov;45(5): 963-73.

 

8. Tugues S, Burkhard SH, Ohs I, Vrohlings M, Nussbaum K, Vom Berg J, Kulig P, Becher B (2015). New insights into IL-12-mediated tumor suppression.

Cell Death and Differentiation. Feb;22(2): 237-46.

 

9. Tugues S, Honjo S, König C, Noguer O, Hedlund M, Botling J, Deschoemaeker S, Wenes M, Rolny C, Jahnen-Dechent W, Mazzone M, Claesson-Welsh L (2012). Genetic deficiency of plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization.

Cancer Research. Apr; 72(8): 1953-63.

 

10. Claesson-Welsh L and Tugues S (2012). Histidine-rich glycoprotein, an endogenous regulator of macrophage and endothelial biology.

Current Angiogenesis. Jun; 1(2): 81-87.

 

11. Tugues S, Koch S, Gualandi L, Li X and Claesson-Welsh L (2011). Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancer.

Mol Aspects Med. Apr; 32:88-111.

 

12. Rolny C*, Mazzone M*, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, Costa S, Vinckier S, Dresselaer T, Åkerud P, De Mol M, Salomäki H, Phillipson M, Wyns S, Larsson E, Buysschaert I, Botling J, Himmelreich U, Van Ginderachter JA, De Palma M, Dewerchin M, Claesson-Welsh L*, Carmeliet P* (2011). * Equal contribution. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

Cancer Cell. Jan; 18: 31-44.

 

13. Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S, Van Steenkiste C, Tugues S, Rolny C, De Mol M, Dettori D, Hainaud P, Coenegrachts L, Contreres JO, Van Bergen T, Cuervo H, Xiao WH, Le Henaff C, Buysschaert I, Kharabi Masouleh B, Geerts A, Schomber T, Bonnin P, Lambert V, Haustraete J, Zacchigna S, Rakic JM, Jiménez W, Noël A, Giacca M, Colle I, Foidart JM, Tobelem G, Morales-Ruiz M, Vilar J, Maxwell P, Vinores SA, Carmeliet G, Dewerchin M, Claesson-Welsh L, Dupuy E, Van Vlierberghe H, Christofori G, Mazzone M, Detmar M, Collen D, Carmeliet P (2010). Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.

Cell. Apr; 141: 178-90.

 

14. Melgar-Lesmes P, Tugues S, Morales-Ruiz M, Ros J, Fernández-Varo G, Arroyo V, Rodés J, Jiménez W (2009). Vascular endothelial growth factor type A (VEGF-A) and Angiopoietin-2 (Ang-2) are relevant in the pathogenesis of the increased vascular permeability in cirrhosis.

Gut. Feb; 58(2): 285-92.

 

15. Tugues S, Fernández-Varo G, Muñoz-Luque J, Ros J, Arroyo V, Rodes J, Friedman SL, Carmeliet P, Jiménez W, Morales-Ruiz M (2007). Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis and portal pressure in cirrhotic rats.

Hepatology. Dec; 46: 1919-26.

 

16. Tugues S, Morales-Ruiz M, Fernández-Varo G, Ros J, Arteta D, Muñoz-Luque J, Arroyo V, Rodes J, Jiménez W (2005). Microarray analysis of endothelial differentially expressed genes in liver of cirrhotic rats.

Gastroenterology. Nov; 129: 1686-95.