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Institute of Experimental Immunology Neuroimmunology

Selected Original publications

  1. Villar, J., De Feo, D., Clément, P., Meuffels, E., Bugada, V., Ingelfinger, F., Ulutekin, C., Kim, J., Pena-Francesch, M., Schmidt, K.W., …Mundt, S. (2024). Monocyte-Derived Cells But Not Microglia Cause Oxidative Tissue Damage in Neuroinflammation. Preprint at Social Science Research Network (under review in Neuron), https://doi.org/10.2139/ssrn.5022504, and bioRxiv https://doi.org/10.1101/2024.09.18.612891
  2. Ingelfinger, F., Kuiper, K. L., Ulutekin, C., Rindlisbacher, L., Mundt, S., Gerdes, L. A., Smolders, J., van Luijn, M. M., & Becher, B. (2024). Twin study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis. Med (New York, N.Y.), 5(4), 368–373.e3. https://doi.org/10.1016/j.medj.2024.02.013
  3. Ulutekin, C., Galli, E., Schreiner, B., Khademi, M., Callegari, I., Piehl, F., Sanderson, N., Kirschenbaum, D., Mundt, S., Filippi, M., Furlan, R., Olsson, T., Derfuss, T., Ingelfinger, F., & Becher, B. (2024). B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis. Cell reports. Medicine, 5(1), 101351. https://doi.org/10.1016/j.xcrm.2023.101351
  4. Andreadou, M.; Ingelfinger, F.; De Feo, D.; Friebel, E.; Tuzlak, S.; Cramer, T. M. L.; Schreiner, B.; Eede, P.; Schneeberger, S.; Geesdorf, M.; Ridder, F.; Welsh, C.; Kirschenbaum, D.; Tyagarajan, S. K.; Greter, M.; Heppner, F. L.; Mundt, S.*; Becher, B.* Neuroprotective Tissue Adaptation Induced by IL-12 Attenuates CNS Inflammation. Nature Neuroscience 2023. doi.org/10.1038/s41593-023-01435-z 
    *Shared last authorship
  5. Ingelfinger, F., Gerdes, L. A., Kavaka, V., Krishnarajah, S., Friebel, E., Galli, E., Zwicky, P., Furrer, R., Peukert, C., Dutertre, C. A., Eglseer, K. M., Ginhoux, F., Flierl-Hecht, A., Kümpfel, T., De Feo, D., Schreiner, B., Mundt, S., Kerschensteiner, M., Hohlfeld, R., Beltrán, E., … Becher, B. (2022). Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature, 603(7899), 152–158. https://doi.org/10.1038/s41586-022-04419-4 
  6. Zwicky, P., Ingelfinger, F., Silva de Melo, B. M., Ruchti, F., Schärli, S., Puertas, N., Lutz, M., Phan, T. S., Kündig, T. M., Levesque, M. P., Maul, J. T., Schlapbach, C., LeibundGut-Landmann, S., Mundt, S. *, & Becher, B. * (2021). IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Science immunology, 6(64), eabg9012. https://doi.org/10.1126/sciimmunol.abg9012 
    *Shared last authorship
  7. Keller, C. W., Kotur, M. B., Mundt, S., Dokalis, N., Ligeon, L. A., Shah, A. M., Prinz, M., Becher, B., Münz, C., & Lünemann, J. D. (2021). CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation. Autophagy, 17(5), 1244–1258. https://doi.org/10.1080/15548627.2020.1756678 
  8. Mundt, S., Mrdjen, D., Utz, S. G., Greter, M., Schreiner, B., & Becher, B. (2019). Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation. Science immunology, 4(31), eaau8380. https://doi.org/10.1126/sciimmunol.aau8380. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript
  9. Keller, C. W., Sina, C., Kotur, M. B., Ramelli, G., Mundt, S., Quast, I., Ligeon, L. A., Weber, P., Becher, B., Münz, C., & Lünemann, J. D. (2017). ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11228–E11237. https://doi.org/10.1073/pnas.1713664114. 
  10. Basler, M.*, Mundt, S.*, Muchamuel, T.*, Moll, C., Jiang, J., Groettrup, M., & Kirk, C. J. (2014). Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO molecular medicine, 6(2), 226–238. https://doi.org/10.1002/emmm.201303543. *Shared first authorship

Selected Reviews and Previews

  1. Gogoleva, V. S., Mundt, S., De Feo, D., & Becher, B. (2024). Mononuclear phagocytes in autoimmune neuroinflammation. Trends in immunology, 45(10), 814–823. https://doi.org/10.1016/j.it.2024.08.005
  2. Keller, C. W., Mundt, S., & Segal, B. M. (2024). Editorial: CNS myeloid cell function in health and disease. Frontiers in immunology, 15, 1459138. https://doi.org/10.3389/fimmu.2024.1459138
  3. Mundt, S., Greter, M., & Becher, B. (2022). The CNS mononuclear phagocyte system in health and disease. Neuron, 110(21), 3497–3512. https://doi.org/10.1016/j.neuron.2022.10.005. 
  4. Mundt, S., Keller, A., & Greter, M. (2021). The dural sinus hub: more than just a brain drain. Cell, 184(4), 858–860. https://doi.org/10.1016/j.cell.2021.01.040
  5. Mundt, S., Greter, M., Flügel, A., & Becher, B. (2019). The CNS Immune Landscape from the Viewpoint of a T Cell. Trends in neurosciences, 42(10), 667–679. https://doi.org/10.1016/j.tins.2019.07.008. 
  6. Basler, M., Mundt, S., Bitzer, A., Schmidt, C., & Groettrup, M. (2015). The immunoproteasome: a novel drug target for autoimmune diseases. Clinical and experimental rheumatology, 33(4 Suppl 92), S74–S79.