Publications

Journal articles:

Shanzhi Wang, Kyeryoung Lee, Richard Chahwan, Yongwei Zhang, Catherine Tang, Sergio Roa, Rikke B. Morrish, Elisa Pesenti, Paula E. Cohen, Thomas MacCarthy, Winfried Edelmann, Matthew Scharff, and Chahwan R*, (In preparation). Dissecting the roles of the enzymatic and scaffolding functions of EXO1 in vivo.

 

Sheppard EC, Morrish RB, Dillon MJ, Leyland R, Chahwan R* (2018). Epigenomic modifications mediating antibody maturation. Frontiers in Immunology, 9(FEB).

 

Harmer NJ, Chahwan R*. Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens. Virulence, 7(6), 623-626.

 

Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T (2015). Overlapping hotspots in CDRs are critical sites for V region diversification. Proc Natl Acad Sci U S A, 112(7), E728-E737.

 

Van Oers JMM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, et al (2014). The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. Oncogene, 33(30), 3939-3946.

 

Chahwan R*, Gravel S, Matsusaka T, Jackson SP (2013). Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. Cell Cycle, 12(6), 1000-1008.

 

Chahwan R, Schaetzlein S, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, et al (2013). Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A, 110(27), E2470-E2479.

 

Chahwan R*, Gravel S, Matsusaka T, Jackson SP (2013). RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures. Cell Cycle, 12(8), 1161-1162.

 

Chahwan R, Edelmann W, Scharff MD, Roa S (2012). AIDing antibody diversity by error-prone mismatch repair. Semin Immunol, 24(4), 293-300.

 

Chahwan C, Chahwan R* (2012). Aicardi-Goutieres syndrome: from patients to genes and beyond. Clin Genet, 81(5), 413-420.

 

Chahwan R, van Oers JMM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S (2012). The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. J Exp Med, 209(4), 671-678.

 

Chahwan R, Edelmann W, Scharff MD, Roa S (2011). Mismatch-mediated error prone repair at the immunoglobulin genes. Biomed Pharmacother, 65(8), 529-536.

 

Chahwan R*, Wontakal SN, Roa S (2011). The multidimensional nature of epigenetic information and its role in disease. Discov Med, 11(58), 233-243.

 

Chahwan R, Wontakal SN, Roa S (2010). Crosstalk between genetic and epigenetic information through cytosine deamination. Trends Genet, 26(10), 443-448.

 

Chahwan R, Ramachandran S, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A, et al (2010). The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A, 107(2), 809-814.

 

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, et al (2007). Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science, 318(5856), 1637-1640. 
 

McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, et al (2004). Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science, 304(5678), 1822-1826.

 

Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, et al (2003). Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J, 22(22), 6137-6147.

 

Matar GM, Chahwan R, Fuleihan N, Uwaydah M, Hadi U (2001). PCR-based detection, restriction endonuclease analysis, and transcription of tonB in Haemophilus influenzae and Haemophilus parainfluenzae isolates obtained from children undergoing tonsillectomy and adenoidectomy. Clin Diagn Lab Immunol, 8(2), 221-224.

 

Book Chapters

Wang S, Chahwan R, Wei L, Scharff MD. Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation. In  (Ed) Encyclopedia of Immunobiology, Elsevier.

 

Martin A, Chahwan R, Parsa JY, Scharff MD (2014). Somatic Hypermutation: the Molecular Mechanisms Underlying the Production of Effective High-Affinity Antibodies. The Molecular Mechanisms Underlying the Production of Effective High-Affinity Antibodies. In  (Ed) Molecular Biology of B Cells: Second Edition, 363-388.