Key Publications

Becher B, Tugues S, Greter M. GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation.
Immunity. 2016 Nov 15;45(5):963-973. doi: 10.1016

Buttgereit A, Lelios I, Yu X, Vrohlings M, Krakoski NR, Gautier EL, Nishinakamura R, Becher B, Greter M. Sall1 is a transcriptional regulator defining microglia identity and function. Nat Immunol. 2016 Dec;17(12):1397-1406. doi: 10.1038/ni.3585

Greter M. Family ties among CNS macrophages. Nat Immunol. 2016 Jun 21;17(7):742-3

Croxford AL, Lanzinger M, Hartmann FJ, Schreiner B, Mair F, Pelczar P, Clausen BE, Jung S, Greter M, Becher B. The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2(+) Monocytes and Licenses Autoimmunity. Immunity. 2015 Sep 15;43(3):502-14

Hoeffel G, Chen J, Lavin Y, Low D, Almeida FF, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JK, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F. C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages.
Immunity. 2015 Apr 21;42(4):665-78

Becher B, Schlitzer A, Chen J, Mair F, Sumatoh HR, Teng KW, Low D, Ruedl C, RiccardiCastagnoli P, Poidinger M, Greter M, Ginhoux F, Newell EW. High-dimensional analysis of the murine myeloid cell system. Nat Immunol. 2014 Dec;15(12):1181-9.

Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, Kündig TM, Frei K, Ginhoux F, Merad M, Becher B. Stroma-derived IL-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia. Immunity, 2012 Dec 14;37(6):1050-60

Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom A, Ma’ayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ, and the Immunological Genome Consortium. Gene expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol, 2012 Nov;13(11):1118-1128

Greter M, Helft J, Leboeuf  M, Bogunovic M, Miller J, Chow A, Hashimoto D, Gautier E, Aloman C, Xiong H, Randolph GJ, Merad M. (2012). GM-CSF controls the development of nonlymphoid tissue dendritic cells but is dispensable for the differentiation of inflammatory dendritic cells. Immunity, 2012 Jun 29;36(6):1031-46

Ginhoux F, Greter M, Leboeuf  M, Gouon-Evans V, Stanley RE, Samokvalov IM, Merad M. Fate mapping studies reveal that adult microglia derive from primitive macrophages.
Science, 2010 Nov 5;330(6005):841-5

Greter M, Hofmann J, Becher B. Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity. PLoS Biol, 2009 May 5;7(5):e1000109

Greter M, Heppner FL, Lemos MP, Odermatt BM, Goebels N, Laufer T, Noelle RJ, Becher B. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.
Nat Med, 2005 Mar;11(3):328-334

Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hovelmeyer N, Waisman A, Rulicke T, Prinz M, Priller J, Becher B, Aguzzi A. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med, 2005 Feb;11(2):146-152