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Myeloid Cell Immunology

Macrophages are present in all tissues and are critical for pathogen clearance, removal of dying cells and orchestrating inflammatory responses. Tissue resident macrophages (TRMs) also support organ integrity, homeostasis and function, and display heterogeneity in their ontogeny, turnover and functional specializations across health and disease.
Our group is interested in the development, regulation and functions of mononuclear phagocytes in both physiological and pathological conditions, with a particular focus on the central nervous system (CNS) and the maternal-fetal interface. In the CNS, distinct macrophage populations include parenchymal microglia and border-associated macrophages (BAMs), which reside in the meninges, choroid plexus and perivascular spaces. We investigate how microglia and BAMs contribute to brain homeostasis, neuroinflammation, and neurodegeneration across development and adulthood. We also study the ontogeny and functions of placental fetal macrophages, aiming to clarify their roles in normal development and in pregnancy complications.